Signal transduction systems and atrial fibrillation

Activation of the calcineurin-nuclear factor of activated T-cell signal transduction pathway in atrial fibrillation.

STUDY OBJECTIVES The calcineurin-nuclear factor of activated T-cell (NFAT) signal transduction pathway regulates the expression of a plethora of genes in the myocardium. Cytosolic calcium overloading occurs in atrial fibrillation (AF), and this fulfills the condition needed for activation of this pathway. We therefore investigated the NFAT pathway in atrial tissue in a porcine model of AF. ME...

Applications of Signal Analysis to Atrial Fibrillation

Signal transduction systems regulating fruit ripening.

Fruit ripening is a unique aspect of plant development with direct implications for a large component of the food supply and related areas of human health and nutrition. Recent advances in ripening research have given insights into the molecular basis of conserved developmental signals coordinating the ripening process and suggest that sequences related to floral development genes might be logi...

Modeling Signal Transduction Using P Systems

Cellular signalling pathways are fundamental to the control and regulation of cell behaviour. Understanding of biosignalling network functions is crucial to the study of different diseases and to the design of effective therapies. In this paper we present P systems as a feasible computational modelling tool for cellular signalling pathways that takes into consideration the discrete character of...

Systems biological analyses of intracellular signal transduction